Two Birds with One Metallic Stone: Single-Pot Catalysis of Fundamentally Different Transformations

✍ Scribed by Alain Ajamian; James L. Gleason

• Book ID: 101560341
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 169 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200301727

✦ Synopsis

Abstract

Advances in metal catalysis have revolutionized organic synthesis, with the scope of metal‐catalyzed reactions now covering nearly all areas of carbon–carbon, carbon–hydrogen, and carbon–heteroatom bond formation. For years, the goal was to develop catalysts that were highly selective for a single transformation. However, a promising current area of research is the use of a single catalyst to mediate more than one transformation in a selective manner. Whereas much early work was focused on using a catalyst for several similar transformations, recent investigations have shown that it is also possible to employ a single catalyst for several very different transformations in a single reaction sequence. This Minireview focuses on methods in which the mechanisms of the transformations are fundamentally very different.