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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

✍ Scribed by Jing Yang; Sendurai A Mani; Joana Liu Donaher; Sridhar Ramaswamy; Raphael A Itzykson; Christophe Come; Pierre Savagner; Inna Gitelman; Andrea Richardson; Robert A Weinberg

Book ID
116352289
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
740 KB
Volume
117
Category
Article
ISSN
0092-8674

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## Abstract Giant cell tumor of bone (GCT) is an aggressive tumor consisting of multinucleated osteoclast‐like giant cells and proliferating osteoblast‐like stromal cells. Our group has reported that the stromal cells express high levels of the bone resorbing matrix metalloproteinase (MMP)‐13, and