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Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage commitment

✍ Scribed by Liu, Xiao-Yan; Dong, Cheng-Ya; Wang, Nan; Guo, Dan; Zhao, Yang-Yang; Ma, Xiao-Tong


Book ID
125818375
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
53 KB
Volume
42
Category
Article
ISSN
0301-472X

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## Abstract Self‐renewal of human embryonic stem (hES) cells proceeds by a unique abbreviated cell cycle with a shortened G1 phase and distinctions in molecular cell cycle regulatory parameters. In this study, we show that early lineage‐commitment of pluripotent hES cells modifies cell cycle kineti