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TWEAK signals through JAK–STAT to induce tumor cell apoptosis

✍ Scribed by Mark S. Chapman; Lan Wu; Aldo Amatucci; Steffan N. Ho; Jennifer S. Michaelson


Book ID
119224967
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
826 KB
Volume
61
Category
Article
ISSN
1043-4666

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## Abstract Experimental evidence documents that the __MDA‐7__/__IL‐24__ protein (an IL‐10 family cytokine) binds to IL‐20 and IL‐22 receptor complexes resulting in the activation of JAK/STAT signaling pathways. Recent published reports utilizing human blood derived primary lymphocytes have provide