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Turnover of hepatic cytochrome P-450 in experimental cholestasis

✍ Scribed by Helmut Denk; Helmut Greim; Ferenc Hutterer; Fenton Schaffner; Hans Popper

Book ID
113146989
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
454 KB
Volume
19
Category
Article
ISSN
0014-4800

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## Abstract Significant changes in drug‐metabolizing enzyme (DME) expression occur during ontogeny. Such changes can have a profound effect on therapeutic efficacy in the fetus and child, as well as the risk for adverse drug reactions. To gain a better understanding of DME ontogeny, enzyme contents