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Turnover of 4-hydroxy-2-nonenal-modified proteins: role of ubiquitin/proteasome pathway

โœ Scribed by Kunihiko Okada; Toshihiko Osawa; Koji Uchida

Book ID
114278161
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
159 KB
Volume
27
Category
Article
ISSN
0891-5849

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To study the possible involvement of reactive oxygen species (ROS) in the tumor biology of human renal-cell carcinoma (RCC), we analyzed 35 cases of RCC for 2 parameters of oxidative damage: 8-hydroxy-2'-deoxyguanosine (8-OHdG), a mutation-prone DNA-base-modified product, was measured by means of hi