Turning it up a Notch: cross-talk between TGFβ and Notch signaling

✍ Scribed by Michael Klüppel; Jeffrey L. Wrana

• Book ID: 101706863
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 84 KB
• Volume: 27
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.20187

✦ Synopsis

Signaling through both the transforming growth factor b (TGFb) superfamily of growth factors and Notch play crucial roles during embryonic pattern formation and cell fate determination. Although both pathways are able to exert similar biological responses in certain cell types, a functional interaction between these two signaling pathways has not been described. Now, three papers provide evidence of both synergy and antagonism between TGFb and Notch signaling. (1)(2)(3) These reports describe a requirement for Notch signal transducers in TGFb-and BMP-induced expression of Notch target genes, as well as in BMP-controlled cell differentiation and migration. These papers uncover a direct link between the Notch and TGFb pathways and suggest a critical role for Notch in some of the biological responses to TGFb family signaling.