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Tumour suppressors: Motoring on down

✍ Scribed by McCarthy, Nicola

Book ID: 109948087
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 303 KB
Volume: 8
Category: Article
ISSN: 1474-1776
DOI: 10.1038/nrc2377

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Two molecular pathways leading to cancer are known. Common-type cancers arise from the 'tumour suppressor' pathway, characterized by gross chromosomal changes and allelic losses (LOH) in an average of 25 per cent or more of randomly chosen chromosomal loci. The 'mutator pathway' has been recognized