Tumour necrosis factor in neonatal listeriosis: a case report

✍ Scribed by E. Girardin; M. Berner; G. E. Grau; J.-M. Dayer; P. Roux-Lombard; S. Suter

• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 191 KB
• Volume: 148
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00441521

✦ Synopsis

A newborn with fatal neonatal listeriosis developed septic shock, neutropenia, thrombocytopenia and profound hypoxaemia due to severe pulmonary hypertension. Tumour necrosis factor et, interleukin-l-[3 and interferon-7 serum concentrations were markedly elevated, suggesting the participation of these cytokines in the aetiopathogenesis of shock induced by Listeria monocytogenes in the neonate. Table 1. Serum cytokine concentrations Cytokines Normal values TNF-ct (pg/ml) 4400 < 150 IL-113 (pg/ml) 900 < 300 IFN-a (u/ml) 15.34 0-11 IFN-7 (u/ml) 1.2 Not detected