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Tumour metastasis in mice with reduced immune reactivity. I. Studies with two MCA-induced sarcomas in radiation and thymectomized radiation C57BL/6J chimeras

✍ Scribed by Bernt Boeryd; Mart Suurküla

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
404 KB
Volume
12
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Spontaneous metastasis formation from two MCA‐induced sarcomas with different degrees of antigenicity was studied in radiation and thymectomized radiation C57BL/6J chimeras. The immune reactivity of the thymectomized chimeras was tested with one of the tumours and it disclosed no specific immune response. Tumour growth was decreased in the chimeras. Spontaneous metastasis formation was not influenced in either of the tumours by the immune suppressive treatment. The results could mean that immune factors have no influence on metastasis formation in the two systems tested, or that the immune suppressive treatment might not have influenced an interplay between presumed facilitating and inhibiting immune factors.

📜 SIMILAR VOLUMES

Tumour metastasis in mice with reduced i
Tumour metastasis in mice with reduced immune reactivity. II. Studies with a highly antigenic MCA-induced sarcoma in thymectomized and/or sub-lethally irradiated C57BL/6J mice
✍ Mart Suurküla; Bernt Boeryd 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 555 KB

## Abstract Spontaneous metastasis formation was studied in thymectomized and/or sublethally irradiated syngeneic C57BL/6J mice of a highly antigenic MCA‐induced sarcoma. The tumour has a low incidence of mainly pulmonary metastases in normal mice. The tumour was transplanted between 1 day and 3 mo

Tumour metastasis in mice with reduced i
Tumour metastasis in mice with reduced immune reactivity. III. Studies with three weakly antigenic tumours in thymectomized and/or sub-lethally irradiated mice
✍ Mart Suurküla; Bernt Boeryd 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 547 KB

## Abstract A previous observation that increased spontaneous metastasis formation from the highly antigenic MCA‐induced sarcoma MCG101 occurred in immunosuppressed C57BL/6J mice prompted the present study to establish whether or not tumours capable of inducing only weak transplantation resistance