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Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells

✍ Scribed by H. Boulaiz; J. Prados; C. Melguizo; J.A. Marchal; E. Carrillo; M. Peran; F. Rodríguez-Serrano; A. Martínez-Amat; O. Caba; F. Hita; A. Concha; A. Aránega

Book ID: 108670156
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 619 KB
Volume: 159
Category: Article
ISSN: 0007-0963
DOI: 10.1111/j.1365-2133.2008.08688.x

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## Abstract Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/ molecular interactions leading to TNF gene expression in macrophages are unknown. The __in vitro__ system in which human blood monocytes are stimulated with human c