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Tumour excision plus continuous tamoxifen compared with modified radical mastectomy in patients over 70 years of age with operable breast cancer

✍ Scribed by Prof. Jacobus Alwyn Van Zyl; Anna Gertruida S. Muller

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 285 KB
Volume: 59
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930590304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Between 1985 and 1991, we randomly assigned 77 women over the age of 70 years with stage I‐3a breast cancer to undergo a modified radical mastectomy or tumour excision followed by tamoxifen. Median follow‐up was 45 months.

Patients treated by tumour excision and tamoxifen had a significantly better survival (P = 0.04). The disease‐free survival of the tumour excision and tamoxifen group was close to significantly better (P = 0.10).

Only two patients in the tamoxifen group required an axillary dissection on follow‐up for progressive nodal enlargement. Two patients underwent a local mastectomy for locally recurrent disease.

We conclude that tumour excision followed by continous tamoxifen is an acceptable, safe alternative to a modified radical mastectomy in patients over 70 years of age.

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Late follow-up of a randomized trial of surgery plus tamoxifen versus tamoxifen alone in women aged over 70 years with operable breast cancer

✍ M. Fennessy; T. Bates; K. MacRae; D. Riley; J. Houghton; M. Baum 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB 👁 2 views

## Abstract ## Background Breast cancer has been considered a more indolent disease in the elderly, who are less tolerant of aggressive therapy. This trial tested the hypothesis that tamoxifen without surgery would provide adequate control of breast cancer for the remainder of life in elderly wome