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Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

✍ Scribed by Groh, Veronika; Wu, Jennifer; Yee, Cassian; Spies, Thomas


Book ID
109890591
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
371 KB
Volume
419
Category
Article
ISSN
0028-0836

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## Abstract NKG2D operates as an activating receptor on natural killer (NK) cells and costimulates the effector function of Ξ±Ξ² CD8^+^ T cells. Ligands of NKG2D, the MHC class I chain‐related (MIC) and UL16 binding protein (ULBP) molecules, are expressed on a variety of human tumors, including melan