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Tumour angiogenesis factor (TAF) and its neutralisation by a xenogeneic antiserum

✍ Scribed by Paul Phillips; Shant Kumar

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
626 KB
Volume
23
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Tumour angiogenesis factor (TAF) has been extracted from a variety of animal and human tumours. Its ability to induce neovascularization in two bioassays, viz. rat air‐sac and chick chorio‐allantoic membrane, is demonstrated. Similar extracts from normal tissues fail to induce angiogenesis. TAF extracts have been used to raise a xenogeneic antiserum, the specificity of which was investigated using classical immunological methods. Its ability to neutralize the biological activity of TAF using the two in vivo assays, was also demonstrated.

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