Tumorigenicity of human bk papovavirus plaque isolates, wild-type and plaque morphology mutant, in hamsters
✍ Scribed by Sumie Watanabe; Setsuko Kotake; Akemi Nozawa; Seijiro Uchida; Takeshi Muto
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 367 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The polyoncogenic prototype human papovavirus BKV (Gardner's strain) produced clear, small and large plaques. Two small‐plaque isolates (wt‐500 and wt‐502), as well as a large‐plaque‐forming isolate (wt‐501), induced frequent brain tumors and occasional osteosarcomas (but no insulinomas) in hamsters. The large‐plaque former (wt‐501) was more tumorigenic than the two small‐plaque isolates. One small (pm‐522) and one large turbid plaque mutant (pm‐525), which had been rescued from hamster tumor cell lines and have small deletion near the origin of DNA replication, induced frequent brain tumors and insulinomas. Mutant 522 was about five times more tumorigenic than wt‐501. These results support the hypothesis that the polyoncogenicity of prototype BKV is accounted for by the presence of BKV mutants.