Tumorigenicity of EBV-carrying lymphoblastoid cell lines (LCLS): Distinctive grading in scid mice

✍ Scribed by Torbjörn Ramqvist; Lennart Norén; Krister Iwarsson; George Klein

• Book ID: 102869995
• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 505 KB
• Volume: 49
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910490420

✦ Synopsis

Abstract

The in vitro and in vivo growth of lymphoblastoid cell lines (LCLs), Burkitt lymphomas (BLs) and PBL‐derived immunoblastomas in SCID mice was studied in parallel. Most, but not all, of the LCLs tested were tumorigenic in SCID mice. Long‐term culturing in vitro was not a necessary prerequisite for tumorigenicity. There was a good correlation between in vivo and in vitro growth. Three major classes of cells could be distinguished on the basis of their growth properties.