๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Tumor vaccination against hepatoma: How does it work?

โœ Scribed by Shuichi Hanada; Takaji Wakita; Hiroshi Takahashi

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
277 KB
Volume
20
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

โœฆ Synopsis

Fusion of BERH-2 rat hepatocellular carcinoma cells with activated B cells produced hybrid cells that lost their tumorigenicity and became immunogenic. Syngeneic rats injected with BERH-2-B hybrid cells became resistant to challenge with parental BERH-2 cells, and rats with established BERH-2 hepatomas were cured by subsequent injection of BERH-2-B cells. Both CD4+ and CDS+ cells were essential for the induction of protective immunity; however, only CD8+ cells were required for the eradication of BERH-2 tumors. The generation of hybrid tumor cells that elicit antitumor immune responses may be a useful strategy for cancer immunotherapy.

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