## Abstract The INK4bβARFβINK4a locus encodes two members of the INK4 family of cyclinβdependent kinase inhibitors, p15^INK4b^ and p16^INK4a^, and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing
β¦ LIBER β¦
Tumor Suppressors Status in Cancer Cell Line Encyclopedia
β Scribed by Sonkin, Dmitriy; Hassan, Mehedi; Murphy, Denis J.; Tatarinova, Tatiana V.
- Book ID
- 120767549
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2013
- Tongue
- English
- Weight
- 471 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1574-7891
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## Abstract Underrepresentation of chromosome 9 is a common finding in bladder cancer. Frequent loss of the whole chromosome suggests the presence of at least one relevant tumor suppressor gene on each arm. Candidate regions identified by loss of heterozygosity (LOH) analysis include a region at 9p