✦ LIBER ✦
Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy
✍ Scribed by Antonio Giordano; Alessandra Rossi; Gaetano Romano; Luigi Bagella
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 139 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Abstract
Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses the potential therapeutic applications both of pRb2/p130 and its derived product Spa310 spacer domain in cancer treatment. J. Cell. Physiol. 213: 403–406, 2007. © 2007 Wiley‐Liss, Inc.