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Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

✍ Scribed by Ke Dong; Rui Wang; Xi Wang; Fang Lin; Jian-Jun Shen; Ping Gao; Hui-Zhong Zhang

Publisher: Springer US
Year: 2008
Tongue: English
Weight: 736 KB
Volume: 113
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-008-9956-x

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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti