Experimental studies in nude mice with human coloncarcinoma grafts demonstrated the therapeutic efficiency of F(abЈ) 2 fragments to carcinoembryonic antigen (CEA) labeled with a high dose of 131 Iodine. A phase I/II study was designed to determine the maximum tolerated dose of 131 I-labeled F(abЈ) 2
Tumor scintigraphy with131I anti CEA monoclonal antibodies andF(ab′)2in colorectal cancer
✍ Scribed by E. Henze; R. Kübel; J. Waitzinger; M. Büchler; W. E. Adam; H. G. Beger
- Book ID
- 104706219
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 627 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0340-6997
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BACKGROUND. This pilot project was undertaken to evaluate the toxicity of and tumor response to combined 13'1 anti-carcinoembryonic antigen monoclonal antibody ('"I anti-CEA RMoAb) and hyperthermia in patients with metastatic colorectal adenocarcinoma.
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