Tumor recurrence and options for further treatment after resection of liver metastases in patients with colorectal cancer
โ Scribed by Peter Hohenberger; Peter Schlag; Volker Schwarz; Christian Herfarth
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 611 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-4790
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## Abstract In animal models, explosive growth of metastases after removal of the primary tumor has been attributed to abolishment of angiogenesis inhibition. We investigated the influence of (removal of) the primary tumor on vascularization of liver metastases in human colorectal cancer patients.
## Abstract The incidence of synchronous and metachronous liver metastases in patients with colorectal cancer is extremely high. Approximately 25 per cent of patients will have overt liver metastases at the time of presentation, and in the remainder up to 40 per cent will eventually develop liver m
We studied the effect of combined chemo-immunotherapy, 5-FU followed by thymosin al (Toll) and interleukin-2 (IL-2) at low doses, on liver metastases from colorectal cancer, induced by splenic injection of DHD/KIZ cells (I ,2-dimethylhydrazineinduced colon adenocarcinoma) in syngeneic BDIX rats. The