Tumor-Promoting Diterpene Esters from Latex of Euphorbia cauducifolia L.
✍ Scribed by Imam Bakhsh Baloch; Musa Kaleem Baloch; Qazi Najam us Saqib
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- German
- Weight
- 78 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Tumor‐promoting characteristics of seven esters, 1–7, obtained from the latex of Euphorbia cauducifolia L. was appraised by carrying out NMRI mice back skin. The structures of 1–7 were elucidated by spectroscopic techniques like ^1^H‐ and ^13^C‐NMR, 2D‐NMR (HMQC, HMBC, HOHAHA (homonuclear Hartmann–Hahn), NOESY, and NOE), FT‐IR, UV, and MS as esters of 17‐hydroxyingenol, namely 17‐[(2__Z__,4__E__,6__Z__)‐deca‐2,4,6‐trienoyloxy]ingenol (1), 3‐O‐angeloyl‐17‐[(2__Z__,4__E__,6__Z__)‐deca‐2,4,6‐trienoyloxy]ingenol (2), 3‐O‐acetyl‐20‐O‐angeloyl‐17‐hydroxyingenol (3), 17‐(acetyloxy)‐3‐O‐angelyl‐ingenol (4), 20‐O‐acetyl‐3‐O‐angeloyl‐17‐hydroxyingenol (5), 3‐O‐angelyl‐17‐(benzoyloxy)ingenol (6) and 20‐O‐acetyl‐3‐O‐angelyl‐17‐(benzoyloxy)ingenol (7). Compounds 1–4 were isolated for the first time, whereas 5–7 are known metabolites but detected for the first time in this plant. Biological investigations revealed that these compounds are tumor promoters.