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Tumor promoter teleocidin inhibits internalization and nuclear accumulation of epidermal growth factor in cultured human hepatoma cells

✍ Scribed by Yoshiyasu Kaneko


Book ID
115913203
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
392 KB
Volume
143
Category
Article
ISSN
0014-5793

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A cloned human hepatoma cell line (Li-7A), possessing epidermal growth factor (EGF) receptors numbering in the range of 10-20 pmol/106 cells, was inhibited in its growth by EGF as well as an antagonist monoclonal antibody (MoAb) to the EGF receptor. The mode of action of the two ligands of EGF recep