Tumor progression of culture-adapted hum
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Sheng Yang; Ge Lin; Yue-Qiu Tan; Di Zhou; Lei-Yu Deng; De-Hua Cheng; Shu-Wei Luo
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Article
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2008
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John Wiley and Sons
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English
β 819 KB
## Abstract Human embryonic stem cells (hESCs) during longβterm culture acquire chromosomal changes similar to those occurring in tumorigenesis. This was raised concerns about the progression from hESCs to malignant cells. This study aimed to investigate the changes in chromosomes, cell phenotype,