Tumor necrosis factor-α triggers cell death of sensitized potassium chloride-stimulated cholinergic neurons
✍ Scribed by Birgit Zassler; Carla Weis; Christian Humpel
- Book ID
- 117386193
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 598 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0169-328X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We examined cytokine-mediated neuronal death in neuron-astrocyte cultures from second trimester human fetal cerebrum. In these cultures, high-output inducible nitric oxide synthase (NOS) and tumor necrosis factor-␣ (TNF␣) are expressed in astrocytes after exposure to IL-1/IFN␥. Neuronal cell death
## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl