Tumor necrosis factor-α suppresses hematopoiesis in children with myelodysplasia

✍ Scribed by Winter, Stuart S.; Hanissian, Gregory A.; Harville, Terry O.; Ware, Russell E.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 121 KB
• Volume: 28
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199701)28:1<69::aid-mpo14>3.0.co;2-5

✦ Synopsis

The term myelodysplasia (MDS) refers to a ence of a soluble factor inhibitory to hematopoigroup of bone marrow failure syndromes which esis. Reverse transcriptase-polymerase chain reare relatively rare in childhood. The pathogene-action (RT-PCR) analysis of total RNA derived sis of MDS is unknown, but a variety of chromo-from the patient's bone marrow mononuclear somal, molecular, and cytochemical abnormali-cells revealed highly elevated tumor necrosis ties have been reported. We describe a 4-month-factor-␣ (TNF-␣) mRNA levels. Using a similar old female with MDS who presented with severe RT-PCR profile, TNF-␣ mRNA levels were found neutropenia and refractory anemia with excess to be elevated in two other children with myeloblasts (RAEB). Bone marrow progenitor cell dysplasia. We conclude that TNF-␣ is produced assays showed decreased erythroid and myeloid in large amounts by bone marrow mononuclear colony formation as compared to normal mar-cells of children with MDS, and we hypothesize row, and the patient's serum further diminished that TNF-␣ plays an important role in the pathocolony formation of both her own and control physiology of the ineffective hematopoiesis obmarrow. These observations suggested the pres-served in MDS.