An increase in gluconeogenesis contributes to the cachexia seen in severe injury, sepsis, and malignancy by converting amino acids from skeletal muscle to glucose. Since tumor necrosis factor a (TNFa) may mediate this cachexia, we examined the effect of this cytokine on gluconeogenesis. Twenty-eight
Tumor necrosis factor α stimulates leukotriene production in vivo
✍ Scribed by Michael Huber; Bruce Beutler; Dietrich Keppler
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 417 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Tumor necrosis factor α (TNF‐α) has come into recent focus as a proinflammatory cytokine derived from monocytes/macrophages. We developed a novel system (the SEK‐5001 system) for measurement of ex vivo production of TNF‐α stimulated by lipopolysaccharide (LPS) as a marker of immune func
The activity of the polyamine biosynthetic enzyme, ornithine decarboxylase (ODC), has been shown to be rapidly modulated by a variety of growth regulatory molecules. In this report the effect of the growth modulatory peptide, tumor necrosis factor, on ODC activity was examined on two cell lines whic