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Tumor necrosis factor α activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells

✍ Scribed by Yuki Kuwano; Kumiko Tominaga; Tsukasa Kawahara; Hidekazu Sasaki; Keiko Takeo; Kensei Nishida; Kiyoshi Masuda; Tomoko Kawai; Shigetada Teshima-Kondo; Kazuhito Rokutan


Book ID
113630682
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
974 KB
Volume
45
Category
Article
ISSN
0891-5849

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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα