Tumor necrosis factor (TNF) neutralization with specific antibodies and TNF-receptor fusion proteins, within the central nervous system (CNS), inhibits the development of experimental allergic encephalomyelitis (EAE)

Control of established experimental alle

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins

✍ David Baker; Debra Butler; Bernard J. Scallon; Janet K. O'Neill; John L. Turk; M 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 1018 KB

## Abstract Tumor necrosis factor (TNF) activity was inhibited during the development of actively‐induced, chronic relapsing experimental allergic encephalomyelitis (CREAE) in Biozzi AB/H mice, using a mouse TNF‐specific (TN3.19.12) antibody and bivalent human p55 and p75 TNF receptor‐immunoglobuli