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Tumor necrosis factor-induced expression of platelet-derived growth factor A-chain messenger RNA in fibroblasts

✍ Scribed by Ylva Paulsson; Rigmor Austgulen; Eva Hofsli; Carl-Henrik Heldin; Bengt Westermark; Jon Nissen-Meyer

Book ID: 115892354
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 971 KB
Volume: 180
Category: Article
ISSN: 0014-4827
DOI: 10.1016/0014-4827(89)90075-x

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## Abstract We have previously found that stimulation of normal neonatal fibroblasts with PDGF or EGF leads to a transient induction of PDGF A‐chain mRNA and the synthesis of PDGF‐AA proteins. This finding may imply the existence of an autocrine feedback mechanism to amplify the mitogenic signal un