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Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats

✍ Scribed by Frank Richter; Gabriel Natura; Stefan Löser; Katarina Schmidt; Hanna Viisanen; Hans-Georg Schaible


Book ID
101652957
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
321 KB
Volume
62
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Pain during mechanical stimulation of the joint and spontaneous pain are major symptoms of arthritis. An important neuronal process of mechanical hypersensitivity of the joint is the sensitization of thin myelinated Aδ fibers and unmyelinated C fibers innervating the joint