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Tumor necrosis factor as a pharmacological target

✍ Scribed by Pietro Ghezzi; Anthony Cerami


Book ID
111640503
Publisher
Humana Press Inc
Year
2005
Tongue
English
Weight
116 KB
Volume
31
Category
Article
ISSN
1073-6085

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One of the mechanisms of cytotoxicity by tumor necrosis factor (TNF) and heat is the induction of reactive oxygen molecules. Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF and heat by inducing manganous superoxide dismutase (MnSOD) to sc