Tumor necrosis factor-? and interleukin-6 release from white blood cells induced by different graft materialsin vitro are affected by pentoxifylline and iloprost
✍ Scribed by Swartbol, P. ;Truedsson, L. ;P�rsson, H. ;Norgren, L.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 312 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
Inflammatory mediators such as cytokines pro-and 10 g/mL, respectively, reduced significantly the TNF-␣ duced by white blood cells (WBCs) at the site of implantation release without differences between the two graft materials, are important for the biocompatibility of vascular grafts. The whereas the effect on the IL-6 release varied and was graft aim of the present study was to demonstrate the tumor necro-material-dependent. In conclusion, graft material-depensis factor-␣ (TNF-␣) and interleukin-6 (IL-6) release from dent induction of TNF-␣ and IL-6 from WBCs was demon-WBCs incubated with expanded polytetrafluoroethylene strated. PTX and ILO influenced the cytokine release. It might (ePTFE) or woven Dacron grafts. In a second series the effects be suggested that graft material-induced cytokine producof pentoxifylline (PTX) and iloprost (ILO), both known to tion could contribute to intimal hyperplasia in vivo. The presinhibit white blood cell function, on this release were deter-ent findings encourage further studies regarding graft matemined. Woven Dacron grafts induced significantly higher rial-induced WBC alterations and the role of pharmacologic release of both TNF-␣ and IL-6 compared to ePTFE. TNF-␣ agents influencing this function. © 1997 John Wiley & Sons, was detectable first after 2 h, whereas IL-6 was seen after Inc. J Biomed Mater Res, 36, 400-406, 1997. 4 h. Maximum values were reached at 6 and 12 h, respectively. The addition of an endotoxin gave more pronounced patterns of cytokine release not influenced by time. Preincu-