Objective. To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. Met
✦ LIBER ✦
Tumor necrosis factor a microsatellite polymorphism is associated with rheumatoid arthritis severity through an interaction with the HLA–DRB1 shared epitope
✍ Scribed by Hua Mu; John J. Chen; Yebin Jiang; Mary-Claire King; Glenys Thomson; Lindsey A. Criswell
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 119 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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## Abstract ## Objective To determine whether the tumor necrosis factor α (__TNFA__) –308 guanine‐to‐adenosine polymorphism and/or the shared epitope (SE) is associated with radiographic damage in patients with early rheumatoid arthritis (RA). ## Methods The cohort consisted of 189 patients with