Tumor Necrosis Factor

✍ Scribed by Toma P. Rossard

• Year: 2009
• Tongue: English
• Leaves: 260
• Edition: 1
• Category: Library

✦ Synopsis

Tumor Necrosis Factor (TNF) is a member of a super family of proteins, each with 157 amino acids, which induce necrosis (death) of tumor cells and possess a wide range of proinflamTumor actions. Tumour necromulti functional multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and the function of endothelial cells lining blood vessels. Blocking the action of TNF has been shown to be beneficial in reducing the inflammation in inflammatory diseases such as Crohn's disease and rheumatoid arthritis. Inappropriate production of TNF or sustained acsignalingf TNF signalling has been implicated in the pathogenesis of a wide spectrum of human diseases that include cancer, osteoporosis, sepsis, diabetes, and auto-immune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Extensive research within the last two decades has shown that TNF can be a potential therapeutic agent in various diseases. This new important book gathers the latest research from around the globe in this field.

✦ Table of Contents

TUMOR NECROSIS FACTOR......Page 3
TUMOR NECROSIS FACTOR......Page 5
Contents......Page 7
Preface......Page 9
Abstract......Page 15
Introduction......Page 16
TNF......Page 17
TNF Receptor......Page 21
TNF Ligand-Receptor Interactions......Page 27
Lymphotoxin......Page 32
Functional Role of TNF......Page 33
TNF Induced Apoptosis/Programmed Cell Death (PCD)......Page 35
Genetic Diversity of TNF and Human Abnormalities......Page 36
Anti-TNF Therapeutics......Page 39
Conclusion......Page 44
References......Page 45
Abstract......Page 63
Common Symptoms, Diagnosis and Extra-Intestinal Manifestations......Page 64
Medical and Surgical Management......Page 65
Development of Intestinal Inflammation in Crohn’s Disease
......Page 67
Role of TNF-α in Crohn's Disease Pathophysiology......Page 72
Infliximab (Remicade™) in Crohn’s Disease Management......Page 76
Other TNF-α Neutralizing Drugs: Experience in CD......Page 80
Adverse Effects of TNF-α Neutralizing Therapy: Data from the Phase III Trial of Drugs Licensed to Date......Page 82
Conclusion......Page 83
References......Page 84
Abstract......Page 93
TNF-α and Chronic Inflammatory Biliary Disease......Page 94
TNF-α and Cholangiocarcinoma......Page 100
References......Page 104
Abstract......Page 109
Discovery of TNF-Alpha - A Historical Perspective......Page 110
Biology of TNF-Alpha......Page 113
Use of RhTNF-Alpha as a Selective Anti-Cancer Agent
......Page 115
Mechanism of Selective Tumor Destruction by RhTNF-Alpha......Page 122
Future Directions......Page 135
References......Page 136
Tumor Necrosis Factor Antagonist Induced Psoriatic Skin Lesions......Page 147
References......Page 151
Abstract......Page 157
Commentary......Page 158
References......Page 162
Abstract......Page 165
Introduction......Page 166
Subjects and Methods......Page 167
Results and Discussion......Page 168
Conclusion......Page 169
References......Page 171
Introduction......Page 173
Condition 1: Human Immunodeficiency Virus Infection Model......Page 174
Conclusion......Page 175
References......Page 176
Introduction......Page 179
Tumor Necrotic Factor in Plasmodium Falciparum Infection......Page 180
Tumor Necrotic Factor in Plasmodium Malariae Infection......Page 181
References......Page 182
Abstract......Page 185
Introduction......Page 186
Our Experience......Page 205
References......Page 208
Abstract......Page 219
Hepatitis B and C Viruses......Page 220
Cytokine Induction During Hepatic Inflammation......Page 221
Relations between TNFα and Cancer and Liver Diseases......Page 222
TNFα and HBV and HCV Infection......Page 223
Anti-TNFα Therapy During HBV and HCV Infection......Page 225
References......Page 226
Index......Page 235