Tumor Microenvironment

✍ Scribed by Dietmar W. Siemann

• Publisher: Wiley
• Year: 2011
• Tongue: English
• Leaves: 463
• Edition: 1
• Category: Library

✦ Synopsis

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.

✦ Table of Contents

Cover......Page 1
Frontmatter......Page 2
Contents......Page 8
Preface......Page 13
List of Contributors......Page 16
Colour plates......Page 20
1 The Microenvironment in Cancer......Page 28
2 Establishing the Tumor Microenvironment......Page 34
3 Contributions of the Extracellular Matrix to Tumorigenesis......Page 62
4 Matrix Metalloproteinases and Their Inhibitors – Friend or Foe......Page 80
5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation......Page 104
6 Bone Marrow Stroma and the Leukemic Microenvironment......Page 126
7 Microenvironment Factors Influencing Skeletal Metastases......Page 162
8 Premetastatic Niches......Page 188
9 Hypoxia, Anerobic Metabolism, and Interstitial Hypertension......Page 210
10 Hypoxia and the DNA Damage Response......Page 234
11 Non-Invasive Imaging of the Tumor Microenvironment......Page 256
12 Hypoxia-Inducible Factor 1 (HIF-1) Mediated Adaptive Responses in the Solid Tumor......Page 298
13 Regulation of the Unfolded Protein Response in Cancer......Page 318
14 Influence of Hypoxia on Metastatic Spread......Page 338
15 Drug Penetration and Therapeutic Resistance......Page 356
16 Impact on Radiotherapy......Page 380
17 HIF-1 Inhibitors for Cancer Therapy......Page 404
18 Vascular-Targeted Molecular Therapy......Page 428
Index......Page 448