𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tumor invasion and angiogenesis in early esophageal squamous cell carcinoma

✍ Scribed by Kuwano, Hiroyuki; Sonoda, Kozo; Yasuda, Mitsuhiro; Sumiyoshi, Kohei; Nozoe, Tadahiro; Sugimachi, Keizo

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
514 KB
Volume
65
Category
Article
ISSN
0022-4790

No coin nor oath required. For personal study only.

✦ Synopsis

Background and objectives:

Although the relationship between angiogenesis and tumor proliferation or malignant potential has been previously demonstrated in several studies, early stage of cancer invasion and angiogenesis has seldom been investigated.

Methods:

From the esophageal specimens of eight recently resected cases with esophageal squamous cell carcinoma, 25 areas of carcinoma-in-situ or microinvasive carcinoma were selected, and then a serial histologic investigation and immunohistochemical staining for the detection of factor viii-related antigen to investigate microvessels in the lamina propria mucosae beneath the lesions as a measure of angiogeneses and staining for laminin to visualize basement membrane was performed. lymphocyte infiltration below the lesions were also estimated. in view of early cancerous invasion, histologic patterns of the growth of the lesions were divided into "flat," "expansive," and "downgrowth" patterns.

Results:

Although downgrowth patterns are thought to be more invasive, relationships between the histologic patterns, and basement membrane staining patterns, and lymphocyte infiltration patterns were not demonstrated. however, the angiogenetic ratio (the number of vessels/cm under the lesions divided by that under normal epithelium) was observed to be significantly and closely related to tumor invasion patterns (p < 0.01), although it was not related to the destruction of the basement membrane or lymphocyte infiltration below the lesions.

Conclusions:

The angiogenesis of esophageal squamous cell carcinoma is closely correlated to the tumor invasion patterns in early esophageal cancerous lesions.

πŸ“œ SIMILAR VOLUMES

Vascular endothelial growth factor expre
Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma : Association with angiogenesis and tumor progression
✍ Kimitoshi Inoue; Yuichi Ozeki; Toshiyuki Suganuma; Yoshiaki Sugiura; Susumu Tana πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 245 KB πŸ‘ 2 views

## Background: Angiogenesis is essential for solid tumor growth and metastasis. vascular endothelial growth factor (vegf), a recently identified growth factor with significant angiogenic properties, may be a major tumor angiogenesis regulator in vivo. conversely, there have been few studies of the

Tumor angiogenesis in T1 oral cavity squ
Tumor angiogenesis in T1 oral cavity squamous cell carcinoma: Role in predicting tumor aggressiveness
✍ Lyon L. Gleich; Paul W. Biddinger; Zlatko P. Pavelic; Jack L. Gluckman πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 565 KB

Background. Angiogenesis is necessary for tumor growth and metastasis. In breast and other cancers angiogenesis has been shown to correlate with tumor size, metastatic potential, and prognosis. Some studies of head and neck cancer have shown a similar correlation, although results are inconclusive.

Thymidine phosphorylase in human esophag
Thymidine phosphorylase in human esophageal squamous cell carcinoma
✍ Yuji Takebayashi; Shoji Natsugoe; Masamichi Baba; Suminori Akiba; Toshitaka Fuku πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 326 KB πŸ‘ 3 views

## Background: Experimental evidence has shown that thymidine phosphorylase (dthdpase) is identical to platelet-derived endothelial cell growth factor (pd-ecgf) and has angiogenic activity. the enzymatic activity of dthdpase was needed for the angiogenesis by the enzyme. these observations were cat