Tumor induction with single urethan injection in newborn and adult syrian golden hamsters. A study on age influence. I.
✍ Scribed by B. Toth
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- French
- Weight
- 383 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Single subcutaneous injections of 1 mg urethan per g body weight were administered to newborn and 8‐week‐old randomly bred Syrian golden hamsters. The treatment ersulted in the induction of higher numbers of forestomach papillomas in animals receiving urethan at adult age than or birth. It gave rise to similar incidences of dermal melamocytomas inthe ovo age groups. Other tumors were also observed in the animals. Since only a few were seen of each type, it is difficult to relate their appearnace to the treatments. It is concluded that ageplays a role inh the oncogenic response of golden hamsters challenged by a single chemical stimulus. The ersults aer discussed in the light of previous studies performed in this field.