✦ LIBER ✦

Tumor-induced angiogenesis: Lack of inhibition by irradiation

✍ Scribed by Robert Auerbach; Robert Arensman; Louis Kubai; Judah Folkman

Publisher: John Wiley and Sons
Year: 1975
Tongue: French
Weight: 420 KB
Volume: 15
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910150209

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of irradiation of tumors on their ability to induce vascular responses (angiogenesis) was studied. Rat Walker carcino‐sarcoma 256, rabbit V2 carcinoma, mouse (C57Bl) melanoma and mouse (129) teratoma (OTT 6050, 100K) were irradiated with up to 5000R, then grafted either to the chicken chorioallantoic membrane or intracorneally into adult rabbits to assess competence to provoke angiogenesis. For all tumors and both assay systems the results were similar: irradiation did not interfere with tumor‐induced vascular responses.

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