𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tumor immunity to murine plasma cell tumors. II. Essential role of T lymphocytes in immune response

✍ Scribed by B. T. Rouse; M. Röllinghoff; N. L. Warner

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
727 KB
Volume
3
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Spleen cells, thoracic duct lymphocytes and adherent peritoneal exudate cells from mice immunized to syngeneic plasma cell tumors were capable of transferring specific protective immunity to these tumors. Pre‐treatment of these cells with anti‐Θ serum or anti‐lymphocyte serum, but not with anti‐ΘK serum, effectively abolished the ability of lymphoid cells to transfer this immune response. These studies demonstrate that T cells are essential in the adoptive transfer of immunity. Furthermore, immunization of athymic (nude) mice to plasma cell tumors was not achieved. Attempts to activate normal macrophages in vitro with sensitized lymphoid cells were unsuccessful. Admixture of immune lymphoid cells and target tumor cells to unrelated tumor cells did not inhibit the growth of the unrelated tumor cells. It is proposed that the immune response to syngeneic tumor associated antigens of plasma cell tumors not only involves essential sensitization of T lymphocytes, but that activated cytotoxic T lymphocytes are directly responsible for inhibiting target tumor growth.

📜 SIMILAR VOLUMES

Tumor immunity to murine plasma-cell tum
Tumor immunity to murine plasma-cell tumors. VIII. Immunosuppression of the generation of cytotoxic T cells by murine plasma-cell tumor lines
✍ Janis V. Giorgi; Noel L. Warner 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 686 KB

## Abstract Previous studies have clearly established that murine plasmacytomas suppress B‐cell responses, but no effects on T‐cell responses have been noted by most investigators. However, in our investigation of the tumor‐associated antigens of plasmacytomas, we have found that immunosuppression

Cd4+ T cells recovered from a mixed immu
Cd4+ T cells recovered from a mixed immune lymphocyte-tumor cell culture induce thymidine incorporation by naive rat lymphocytes in response to tumor cells
✍ Danièle Reisser; François Martin 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 618 KB

## Abstract Spleen cells from tumor‐immune rats incorporate thymidine when co‐cultured for 4 days with syngeneic cancer cells. Non‐adherent cells, recovered from a 7‐day mixed culture with cancer cells, had lost their capacity for incorporating thymidine when exposed again to the same tumor cells;

Suppressor pathways in tumor immunity: A
Suppressor pathways in tumor immunity: A requirement for Qa-1 positive tumor-bearer spleen t cells in suppression of the afferent immune response to tumor antigens
✍ James J. Mulé; Thomas H. Stanton; Ingegerd Hellström; Karl Erik Hellström 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 734 KB

## Abstract Spleen cells from mice bearing large methylcholanthrene (MCA)‐induced sarcomas were injected intravenously into mice challenged in the hind footpads with heavily‐irradiated cells from the same or a different sarcoma. As measured by [^3^H]‐thymidine incorporation on day 5 or 6, cellular

Proliferative response of T cells from t
Proliferative response of T cells from tumor-immune chickens to carcinogen-induced fibrosarcoma cells
✍ Pascale Quere; Vincent K. Tsiagbe; G. Jeanette Thorbecke 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 571 KB

## Abstract Immunity to carcinogen‐induced transplantable fibrosarcomas (CHCT‐NYU‐4, ‐97, ‐36 and ‐20) in SC chickens was studied by the ability of spleen cells from NYU‐4 or ‐97 immune chickens to proliferate in response to tumor cells __in vitro__. Spleen, but not peripheral blood cells, from NYU

Tumor immunity to murine plasma cell tum
Tumor immunity to murine plasma cell tumors. V. Demonstration of a unique tumor antigen that is not associated with the myeloma idiotype
✍ M. R. Mackenzie; R. C. Burton; N. L. Warner 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 634 KB

## Abstract A plasma‐cell tumor, Cl.18 of C3H/He derivation, exhibits a unique tumor‐associated antigen (TAA) which is detectable both __in vitro__ and also as a tumor‐associated transplantation antigen (TATA) __in vivo.__ Immunoglobulin idiotypic determinants have been thought to be prominent TATA