✦ LIBER ✦

Tumor IGF-II content in a patient with a colon adenocarcinoma correlates with abnormal expression of the gene

✍ Scribed by Sylvie Lambert; Rosita Gol-Winkler; Julien Collette; Jacqueline Gillis; Paul Franchimont; Claude Desaive

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 575 KB
Volume: 48
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910480607

No coin nor oath required. For personal study only.

✦ Synopsis

We have recently reported abnormal insulin-like growth factor4 (IGF-II) mRNA levels in a number of human colorectal adenocarcinomas. Using an IGF-II radioimmunoassay, we have now detected high levels of both 10-kDa and 7.5-kDa IGF-II species (2,370 ng/g) in a right colon tumor showing a 800-fold IGF-II gene over-expression in comparison to the normal adjacent tissue. The higher-molecular-mass form represents 74% of the total imrnunoreactive IGF-II detected in the tumor. This form appears to be less reactive in the radioreceptor assay than in the radioimmunoassay. The insulinlike growth factor-I (IGF-I) concentration in the tumor is low. The patient's pre-operative serum IGF-II level is not increased and the proportion of the 10-kDa species is normal. In addition, the IGF-II/IGF-I ratio is 3 in the serum and 308 in the tumor. Our results show that the very high IGF-II level produced by the tumor does not influence the seric concentration of the growth factor.

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