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Tumor hypoxia in pelvic recurrences of cervical cancer

✍ Scribed by Michael Höckel; Karlheinz Schlenger; Susanne Höckel; Billur Aral; Uwe Schäffer; Peter Vaupel

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
114 KB
Volume
79
Category
Article
ISSN
0020-7136

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✦ Synopsis

We have previously demonstrated in primary cancer of the uterine cervix that tumor hypoxia, as determined polarographically, is strongly associated with clinical malignant progression of the disease. Having applied a similar methodological approach to investigate loco-regional relapses, we found a pronounced shift to more hypoxic oxygenation profiles in the recurrent tumors than in the primary tumors. Median pO 2 values in 53 pelvic recurrences were significantly lower than the median pO 2 values of 117 primary tumors of comparable sizes (7.1 ؎ 1.1 mmHg vs. 12.1 ؎ 1.0 mmHg, p ‫؍‬ 0.0013). The differences in tumor oxygenation between primary and recurrent tumors mirrored the differences in the patients' 5-year survival probabilities. In the cohort of patients with pelvic relapses, median tumor pO 2 F 4 mmHg indicated a significantly shorter median survival time as compared to median tumor pO 2 H 4 mmHg. Our results further support our thesis that in cervical cancer, tumor hypoxia and clinical aggressiveness in terms of resistance to therapy and tumor dissemination, are interrelated.

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