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Tumor Heterogeneity Confounds and Illuminates: Assessing the implications

โœ Scribed by Kleppe, Maria; Levine, Ross L


Book ID
121662094
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
759 KB
Volume
20
Category
Article
ISSN
1078-8956

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We have designed an in vitro assay to assess the influence of tumor subpopulation interactions on drug response. The assay is based upon inhibition of growth of 1 mm3-pieces of tumor embedded in a collagen gel matrix. Tumor growth is quantitated by planimetry of each colony's image, formed with a sp