✦ LIBER ✦

Tumor expression of Fas ligand (CD95L) and the consequences

✍ Scribed by Paul R Walker; Philippe Saas; Pierre-Yves Dietrich

Book ID: 104358945
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 795 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80225-2

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✦ Synopsis

Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand. The final in vivo outcome of CD95 ligand expression will depend upon a complex balance of interactions relevant for each tumor in its particular microenvironment.

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