As CD40 plays a key role in both antitumor immunity and DC maturation, we have studied the regulation of its expression during DC hematopoiesis (dendropoiesis) in vitro and in vivo in the tumor microenvironment. Using MC38 colon adenocarcinoma tumor models, we have demonstrated that DCs generated in
โฆ LIBER โฆ
Tumor expression of CD200 inhibits IL-10 production by tumor-associated myeloid cells and prevents tumor immune evasion of CTL therapy
โ Scribed by Lixin Wang; Jin-Qing Liu; Fatemeh Talebian; Hani Y. El-Omrani; Mazin Khattabi; Li Yu; Xue-Feng Bai
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 639 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0014-2980
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Our study investigated the ability of peripheral blood mononuclear cells (PBMCs) isolated from patients with different clinical stages of gastric cancer to produce proinflammatory (tumor necrosis factor alpha [TNFalpha], interleukin 12p40 [IL-12p40] and interleukin 6 [IL-6]) and antiinflammatory (in