Purpose:
To determine the signal enhancement characteristics of tumors after administration of a metalloporphyrin derivative, hop-9p (13, 17-bis (1-carboxypropionyl) carbamoylethyl-3, 8-bis (1-phenylpropyloxyethyl)-2, 7, 12, 18-tetramethyl-porphyrinato manganese (iii)) and to determine whether hop-9p is tumor-necrosis specific.
Materials and methods:
Ten c3h/he mice bearing a scc vii tumor in the right flank were examined using t1-weighted conventional spin echo magnetic resonance (mr) imaging before contrast injection, and five minutes, one hour, and 24 hours after intravenous administration of 0.1 mmol/kg of hop-9p. following the imaging schedule, the mice were sacrificed, and sectioned in the same axial planes as the mr images. based on an mr imaging-histopathologic correlation, mean signal intensities were measured, and signal-to-noise ratios (snr) were calculated for both pure viable component and admixture of necrotic and viable component of the tumor.
Results:
Mean snr of the pure viable component peaked at one hour (35.0 +/- 3.8) and maintained that level until 24 hours (34.6 +/- 3.6). mean snr of the admixture of necrotic and viable component peaked at 24 hours (44.3 +/- 12.1).
Conclusion:
Although different enhancement patterns were seen between the pure viable component and the admixture of necrotic and viable component, hop-9p enhanced both of the two components.