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Tumor Endothelial Cell Targeted Cyclic RGD-modified Heparin Derivative: Inhibition of Angiogenesis and Tumor Growth

✍ Scribed by Kyeongsoon Park; Yoo-Shin Kim; Gee Young Lee; Rang-Woon Park; In-San Kim; Sang Yoon Kim; Youngro Byun


Publisher
Springer US
Year
2008
Tongue
English
Weight
664 KB
Volume
25
Category
Article
ISSN
0724-8741

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## Abstract The apurinic/apyrimidinic endonuclease 1/redox factor‐1 (Ape‐1/Ref‐1) is a multi‐functional protein, involved in DNA repair and the activation of redox‐sensitive transcription factors. The Ape‐1/Ref‐1 redox domain acts as a cytoprotective element in normal endothelial cells, mitigating