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Tumor-derived exosomes: a new source of tumor rejection antigens

✍ Scribed by F André; N.E.C Schartz; N Chaput; C Flament; G Raposo; S Amigorena; E Angevin; L Zitvogel

Book ID
117431111
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
54 KB
Volume
20
Category
Article
ISSN
0264-410X

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## Microsatellite instability (MSI) caused by defective DNA mismatch repair (MMR) is a hallmark of hereditary nonpolyposis colorectal cancers (HNPCC) but also occurs in about 15% of sporadic tumors. If instability affects microsatellites in coding regions, translational frameshifts lead to truncate