## Abstract Alterations in the expression of certain genes or in their products can render benign tumor cells metastatic. Experimentally this has been quickly performed by transferring dominantly acting oncogenes such as c‐H‐ras^EJ^ into susceptible cells, but __in vivo__ such a rapid qualitative c
✦ LIBER ✦
Tumor cells as cellular vehicles to deliver gene therapies to metastatic tumors
✍ Scribed by García-Castro, Javier; Martínez-Palacio, Jesús; Lillo, Rosa; García-Sánchez, Félix; Alemany, Ramón; Madero, Luis; Bueren, Juan A; Ramírez, Manuel
- Book ID
- 110019204
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 349 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0929-1903
No coin nor oath required. For personal study only.
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## Abstract ## Background Inhibition of tumor‐induced angiogenesis may restrict tumor growth and metastasis. Long‐term systemic delivery of angiogenic inhibitors is associated with toxicity, as well as other severe side‐effects. The utility of cells as vehicles for gene therapy to deliver therapeu